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Hereditary diffuse gastric cancer: laparoscopic surgical approach associated to rare mutattion of CDH1 gene
Apresentação do caso
Gastric cancer sets among the five most prevalent cancer in Brazil. For the year 2014, according to the National Cancer Institute (INCA), were expected 20,390 new cases with 13,328 deaths from the disease. Despite the identification of risk factors for the occurrence of neoplasia1, approximately 80% of cases are sporadic and not associated with risk factors. Even less frequent, it is the hereditary cases and associated with mutation of the CDH- 1 gene, determining the occurrence of Cancer Hereditary Diffuse Gastric Syndrome. It corresponds to 3% of cases of gastric cancer.
Patients mutation CDH1 gene carriers have shown gastric cancer with more adverse prognosis, as the presence of signet ring cells, poorly differentiated tumors and diffuse histological pattern, making also important to identify families suffering from chromosomal gene changes and syndrome determinants to allow early diagnosis and preventive treatment. As for the surgical treatment of hereditary or not gastric cancer, laparoscopy has demonstrated oncologic results similar to laparotomy approach, and lower morbidity, with patients returning earlier to their activities.
This study aims to report a case diagnosed clinically and genetically, with treatment done through laparoscopic radical gastrectomy.
gastric cancer, CDH1 gene, surgery
Trato gastrointestinal alto*
EURICO CAMPOS, JOSE ARRUDA, LUIS GUSTAVO RACHELLA, FERNANDA PINA, MARCOS ADRIANO JOTA